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Probiotics prevent IgE-associated allergy until age 5 in cesarean-delivered children but not in total cohort
Childhood allergies have increased significantly in industrialized countries during the past few decades. Researchers theorize that this rising incidence is the result of a lowered exposure to bacteria in early childhood. This exposure to microbes appears to be essential in jump-starting the immune system to develop healthy pathways that do not result in allergic conditions.
Additionally, it’s been observed that infants who develop allergies have intestinal bacteria that are distinctly different from those of non-allergic infants, suggesting that the type of intestinal microflora is an important factor in forming allergic conditions.
In a study available online from the Journal of Allergy and Clinical Immunology (www.jacionline.org), researchers from the University and University Hospital of Helsinki, Finland, conducted a clinical trial of more than 1200 mothers whose infants would be at high risk to develop allergies. During the last month of their pregnancies, the mothers took daily doses of a probiotic mixture or a placebo, and their infants were given the same probiotic mixture plus a prebiotic or a placebo for the first 6 months of their lives. The children were followed for 5 years and evaluated for incidence of allergic diseases.
The authors found that the frequencies of allergic and IgE-associated allergic disease and sensitization were similar in the children who had received probiotic and those who’d gotten placebo. Although there appeared to be a preventive effect at age 2, there was none noted at age 5. Interestingly, in babies born by cesarean section, the researchers found less IgE-associated allergic disease in those who had received the probiotic.
“No allergy-preventive effect is extended to age 5 years by perinatal supplementation with probiotics in babies at risk for developing allergies; protection is conferred only to C-section babies. However, it is possible that stronger and longer stimulation of the infant immune system possibly by varying the strains of bacteria, may result in better allergy-preventive effects”, says Dr. Mikael Kuitunen form the Skin and Allergy Hospital of Helsinki University Central Hospital.
Kuitunen M, MD, PhD, Kukkonen K, MD, Juntunen-Backman, MD, PhD, Korpela, Riitta, PhD, Poussa, Tuija, Tuure, Tuula, PhD, Haahtela, Tari, MD, PhD, and Savilahti, Erkki, MD, PhD: Probiotics prevent IgE-associated allergy until age 5 years in
cesarean-delivered children but not in the total cohort. Journal of Allergy and Clinical Immunology. January 2009 (online).